Binding of group 15 and group 16 oxides by a concave host containing an isophthalamide unit

• Jens Eckelmann,
• Vittorio Saggiomo,
• Svenja Fischmann and
• Ulrich Lüning

Beilstein J. Org. Chem. 2012, 8, 11–17, doi:10.3762/bjoc.8.2

• halide anions. A general method for a quick estimation of the strength of binding derived from only a few data points is presented and gives an estimated Kass of pyridine-N-oxide of ca. 40 M−1, NMR titration confirms 25 M−1. Keywords: anion binding; association constant; estimation of binding constants

• is more extreme, and the final value of Δδmax is approached faster than in the case of weak binding. Beyond 1:1 stoichiometry, the CIS values converge more the stronger the binding is. Can this be a method for the quick estimation of binding constants? We have tested this alternative for hosts 1 and